PROGRAMMABLE NANO-MACHINES THE FUTURE OF CANCER THERAPEUTICS
ABSTRACT:History of cancer therapeutics and its evolution in the last 80 years is bringing the limitations and
toxicities associated with past and current cancer treatment modalities to our attention. Fundamental principles of
cancer, namely CIN and ITH should get employed towards generation of future cancer therapeutics. Nano-technology
could potentially enable us to tackle this problem in a fundamentally different way. By shuttling programmable
nano-machine, into the tumor mass we could modify the genetic program and energetics of cancer cells. As such, we
could slow down the speed of progress of cancer down the axis of time. This could potentially make cancer one of the
many chronic diseases rather than a disease that kills the majority of patients within several years following diagnosis.