Fundamentals of Living and Nonliving Universes from Black Holes To Cancer

By Dr. Kambiz Afrasiabi

About the Fundamentals of Living and Nonliving Universes from Black Holes To Cancer

Fundamentals of living and nonliving universes addresses the most fundamental law that governs the known nonliving universe and its extension into the living universes. The author discusses major misconceptions regarding both realms. He introduces three major concepts for the first time:

  1. Infinity wall, which argues with an ever-expanding universe theory that is currently widely accepted in scientific society.
  2. Law of spontaneity, which describes how all the complex intracellular events are happening smoothly.
  3. Quantum supervectors, which reprogram each cell according to its master regulator complex entropy.The author also recognizes the urgent need for generation of a new field of science that he has coined quantum biology and training a new generation of scientists that could handle the massive challenges ahead of us in solving diseases like cancer.
The author also recognizes that a deep understanding of simple events, both in living as well as nonliving universes, should become our major priority before our premature rush toward solving complex problems such as cancer and space travel.

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Fundamentals of living and nonliving universes addresses the most fundamental law that governs the known nonliving universe and its extension into the living universes. The author discusses major misconceptions regarding both realms. He introduces three major concepts for the first time:

About Dr. Kambiz Afrasiabi

The Author of Fundamentals of Living and Nonliving Universes From Black Holes to Cancer

Dr. Kambiz Afrasaibi describes the massive interconnectivity of universal laws, encompassing micro and the macro universe at all levels in his book.
Based on the fundamental laws prevailing the nonliving universe and living universes and their breakdown, he is holding a new point of regards, not only as far as the build-up of the known universe and its destiny is concerned, but also regarding devastating conditions such as malignant disorders.
 
As such, he proposes a new solution to these problems.
 

RESEARCH INTEREST

  • Cancer Biology in general, Bioenergetics specifically as it relates to the second law of thermodynamics and evolution of normal state as well as its perturbances in malignancy
  • Design of the new generation of cancer therapeutics based on the conversion of the malignant cell to normal cell rather than the destruction of a malignant cell through a deep understanding of the normal state
  • Measurement of network landscape energetics or normal cell and its malignant counterpart through methodologies such as liquid nuclear magnetic resonance spectroscopy
  • Quantitative analysis of the net effect of individual discriminative and distinguished mutations on the existing difference in the network landscape energetics of different neoplastic disorders as compared with their normal counterpart by using methodologies such as siRNA against that individual mutation
  • Using mathematical models to decipher and prescribe a tailored and customized neoplastic landscape conversion treatment by applying microRNA, epigenetics science, and systems biology as tools and using Nanotechnology for delivery
Dr.Kambiz_Afrasiabi

PUBLISHED PEER REVIEW ARTICLES (*corresponding author)

  1. Lipkin SM, Afrasiabi K (2007) Familial Colorectal Cancer Syndrome X. Seminars in Oncology, Volume 34, Issue 5, October 2007, pages 425-427. PMID: 17920898
  2. Edwards RA, Witherspoon M, Wang K, Afrasiabi K, Pham T, Birnbaumer L, Lipkin SM (2009). Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer.
  3. Zhoa F, Edwards R, Dizon D, Afrasiabi K, Mastroianni JR, Geyfman M, Ouellette AJ, Anderson
    B, Lipkin SM (2010) Disruption of Paneth and Goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/-mice. Developmental Biology 338 (2010) 270-279. PMID: 20025862
  4. Afrasiabi K (2011). Quantum Stem Cell in the Infinity Loop: A New Model for Our
    Understanding of the Normal State and Cancer. Online Journal of Biological Sciences 10 (2): 60-
    65, 2010. DOI: 10.3844/ojbsci.2010.50.53
  5. Afrasiabi K (2011). Entropyomics as The Blueprint Of The Logic Of Normal Cell Division And Malignancy. Online Journal of Biological Sciences 11(1): 23-26, 2011. DOI: 10.3844 /o jbsci. 2011.23.26
  6. Afrasiabi K (2011) Zero Geometry, Zero Space Time, the Seeds of Final Theory. American Journal of Applied Sciences 8 (11): 1228-1231, 2011. DOI: 10.3844 / ajassp.2011.1228.1231
  7. Afrasiabi K (2012) Bioenergetics, the Foundation of the Future of Cancer Therapeutics, a Quantrum Leap in Making. Online Journal of Biological Sciences, 2012, 12(3), 108-112. DOI 10.3844/ojbsci. 2012.108.112
  8. Afrasiabi K*, Melekh-Shalom J (2013) Free Energy Measurement Distinguishes Normal Cell from Cancer Cell, Offering a New Perspective for Curing Cancer. Online Journal of Biological Sciences 13(4): 121-125, 2013
  9. Afrasiabi K*, Robert Edwards, Jonathan Melek-Shalom and Kehui Wang (2013) Hypoxic Inflammation, a Deadly Bridge To Malignant Transformation and a Fertile Soil for Cancer Prevention. Online Journal of Biological Sciences. 13 (3): 76-81, 2013. DOI: 10.3844/ojbsci. 2013.76.81
  10. Afrasiabi K, Robert Edwards, Kehui Wang (2014). Atra as a potential antimetastatic agent in colorectal adenocarcinoma. Online Journal of Biological Sciences 14(2): 102-197, 2014. DOI: 0.3844/ojbsci.2013.121.125
  11. Afrasiabi K*, Zhou YH, Fleishman A (2015). Chronic Inflammation; is it the driver or is it paving the road for malignant transformation? Genes Cancer. 2015 May; 6(5-6):214-9. PMID: 26124920
  12. Afrasiabi K*, Zhou YH, Fleishman A (2016. GPCRs, at the crossroad of distortion in extracellular microenvironment and intracellular energetics homeostasis, a new model for 21 st century cancer therapeutics. Cancer and Clinical Oncology. Accepted.
  13. Afrasiabi K (April 2017) ZR30. A Novel Protein Therapeutic for Gliomas. Submitted to cancer research
  14. Afrasiabi K, Yanyan Li, Yuan Hu, Chuanjin Liu, Qingyue Wang, Xiaoxiao Han, Young Han, Xue-Shun Xie, Xiong-Hui Chen, Xiang Li, Eric R. Siegel, Mark E. Linskey, You-Xin Zhou, Yi-Hong Zhou (2017). Human fibulin-3 protein variant expresses anti-cancer effects in the malignant glioma extracellular compartment in intracranial xenograft models.
  15. Afrasiabi K, Yi-Hong Zhou, Mark E. Linskey (2017). Mis-segregation of tumor-specific chromosomes modulate intra-tumoral heterogeneity in glioma progression and treatment resistance.
  16. Yi-Hong Zhou, Mark E. Linskey, Kambiz Afrasiabi. Extracellular control of chromosomal instability and maintenance of intra-tumoral heterogeneity. jcmt August 2018
  17. Human Fibulin-3 Variant Targets Vascularization in Glioma Xeografts by Suppression of Angiogenesis and Tumor Cell Endothelial Phenotype. Published in Cancer Science February 2020.
  18. Kambiz Afrasiabi, Mark E. Linskey, Yi-Hong Zhou. Exploiting Cancer’s Evolutionary Tactics to Make Cancer a Chronic Disease. Short Title: Past, Present, and Future Cancer Therapeutics. Published: June 22, 2020.
  19. Kambiz Afrasiabi, M.D. Associate Project Scientist, UCI PROGRAMMABLE NANO-MACHINES THE FUTURE OF CANCER THERAPEUTICS. Published: December 2020 (IJIRSET) Read Article
  20. Kambiz Afrasiabi, M.D. Associate Project Scientist, UCI – Zero Space Time: The Dark Corridor of Science Afrasiabi Pre-force Theory: The Foundation of Future Scientific Theories. Published: December 2020 (IJIRSET) Read Article

Books:

  1. Afrasiabi K, Lipkin SM. New Developments in Array-based Diagnostic Tests Predicting Outcomes in Colorectal Cancer. American Society of Clinical Oncology, Education Book 2007. 1092-9118/07/114-117.
  2. Afrasiabi K. Fundamentals of Living and Non-Living Universes from Black Holes to Cancer. Published July 5, 2018. Registration Number: TX 8-604-434. International Standard Number: ISBN 978-1-64214-736-0. Page Publishing.

Reviews

5 Star Review on Amazon
5/5
Brilliant read! Truly eye-opening and inspiring, a fresh perspective on life and the intertwinement of all matter. Purchased one for each of my siblings as well, perfect for gifting. The cover on its own is enticing and worth it
Shaun O.
5 Star Review on Amazon
5/5
Dr. Afrasiabi challenges the way we have been approaching cancer research for decades, and proposes a unique perspective that will change our thinking. Excellent, insightful book and I look forward to further reads from this author.
Daman Rangoola
5 Star Review on Amazon
5/5
The author has done a great job presenting his ideas in this book!
Clay Deering
5 Star Review on Amazon
5/5
Game changing book that offers a new perspective to age old questions.
Sayeh Akbarpour

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